Regulatory Tripeptide

KPV 10mg

An ultra-short synthetic tripeptide representing the active C-terminal sequence of alpha-melanocyte stimulating hormone. This 3-amino acid chain (C₁₆H₃₀N₄O₄) is extensively researched for its potent anti-inflammatory and immunomodulatory properties.

Molecular Engineering Data

Molecular FormulaC₁₆H₃₀N₄O₄

Molecular Weight342.44 g/mol

CAS Registry67727-97-3

Physical StateAcetate Salt Solid

Primary MechanismNF-κB Pathway Inhibition

Assay (HPLC)>99.0% Purity

Immune Modulation Cascade

KPV represents a unique approach to targeted cellular regulation. Unlike broad immunosuppressants, it functions by heavily downregulating the NF-κB transcription factor pathway while maintaining basal immune function. This targeted mechanism allows researchers to observe rapid reductions in pro-inflammatory cytokines, making it a primary candidate for studying cellular responses to oxidative and inflammatory stress.

NF-κB
Pathway Suppression

Observed to significantly inhibit the nuclear translocation of NF-κB, rapidly reducing the cascade of systemic inflammatory cytokines like TNF-alpha and IL-6.

MC1R
Receptor Activation

Binds directly to specific melanocortin receptors expressed on immune cells, promoting targeted anti-inflammatory signaling without triggering unwanted hormonal side effects.

Structural Blueprint

The 342.44 Da structure (Lys-Pro-Val) is the exact C-terminal fragment of alpha-MSH. Its exceptionally small size allows for rapid cellular uptake, specifically via the PepT1 transporter in intestinal models. This precise three-amino acid sequence provides maximum anti-inflammatory action completely devoid of the pigmentation and metabolic effects seen in the full parent hormone.

KPV Structure

Pharmacological Benchmarks

Base Origin: Alpha-MSH Fragment (ACTH 11-13)
Primary Action: Targeted NF-κB Suppression
Cellular Uptake: High PepT1 Transporter Affinity
Secondary Traits: Mild Antimicrobial Properties
Target Areas: Gut Barrier and Dermal Integrity

Key Research Benchmarks

In preclinical models, KPV is extensively investigated for its targeted effects on Mucosal Inflammation and Epithelial Recovery. Researchers map the rapid suppression of inflammatory markers to determine its volumetric efficacy in combating cellular stress within highly sensitive biological barriers.

Gut Barrier Repair
Investigating the stabilization of intestinal epithelial tight junctions and the reduction of mucosal inflammation in models of induced colitis.

Dermatological Healing
Analysis of accelerated wound closure and the mitigation of localized oxidative stress in keratinocytes and complex epithelial tissues.

Laboratory Protocol & Handling

Storage & Stability
Supplied lyophilised for maximum sequence integrity during logistics.

Dry Storage: -20°C for >12 months; 2-8°C for <6 months.
Liquid Stability: Must be refrigerated (2-8°C) once reconstituted.
Solubility: Water (1mg/ml) or sterile physiological saline.

Reconstitution SOP
Strict adherence to laboratory SOPs is required to maintain the 3-amino acid chain.

Solvent: Sterile Bacteriostatic Water or PBS.
Technique: Slow sidewall induction; do not agitate the puck.
Unit Sizes: 10mg precision research configurations.

Strict Laboratory Compliance Notice

WARNING: This compound is a chemical reagent supplied exclusively for in-vitro and in-vivo laboratory research. It is NOT a drug, medication, or food supplement. Strictly prohibited for human or veterinary administration. Lawful handling is the sole responsibility of the professional user. HRS Distribution assumes no liability for applications outside of laboratory scientific research.