Mitochondrial-Derived Peptide

MOTS-c 40mg

A groundbreaking 16-amino acid peptide encoded by the mitochondrial genome. This unique metabolic regulator (C₁₀₁H₁₅₂N₂₈O₂₂S₂) is extensively researched for its profound effects on energy homeostasis and cellular stress resistance.

Molecular Engineering Data

Molecular FormulaC₁₀₁H₁₅₂N₂₈O₂₂S₂

Molecular Weight2174.6 g/mol

CAS Registry1627580-64-6

Physical StateAcetate Salt Solid

Primary MechanismAMPK Activation

Assay (HPLC)>99.0% Purity

Metabolic Activation Cascade

MOTS-c represents a paradigm shift in metabolic research. Unlike traditional nuclear-encoded peptides, it acts as a retrograde signal from the mitochondria to the nucleus. By directly targeting the folate cycle and powerfully activating AMP-activated protein kinase (AMPK), researchers observe systemic shifts in energy metabolism that closely mimic the physiological effects of rigorous aerobic exercise.

AMPK
Cellular Energy Sensor

Observed to heavily phosphorylate and activate AMPK, driving peripheral tissues (especially skeletal muscle) to increase glucose uptake and shift towards sustained fatty acid oxidation.

AICAR
Folate Cycle Modulation

Inhibits the folate cycle de novo purine biosynthesis pathway, leading to a cellular accumulation of AICAR, which further sustains the metabolic activation loop.

Structural Blueprint

The 2174.6 Da structure (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) is biologically unique as it originates from the 12S ribosomal RNA of the mitochondrial genome. Its specific 16-amino acid configuration allows it to translocate into the nucleus under cellular stress to regulate adaptive metabolic gene expression.

MOTS-c Structure

Pharmacological Benchmarks

Base Origin: Mitochondrial 12S rRNA
Primary Action: Exercise Mimetic / AMPK Agonist
Insulin Sensitivity: Profoundly Enhanced
Metabolism: Shift to Fatty Acid Oxidation
Cellular Target: Skeletal Muscle & Nucleus

Key Research Benchmarks

In preclinical models, MOTS-c is extensively investigated for its targeted effects on Metabolic Dysfunction and Ageing. Researchers map the rapid spikes in cellular glucose uptake to determine its volumetric efficacy in combating diet-induced obesity and age-related metabolic decline.

Exercise Mimetics
Observing the marked increase in skeletal muscle performance, energy expenditure, and endurance capacity under rigorous metabolic testing paradigms.

Cytoprotection
Analysis of cellular resistance to metabolic stress, focusing on the reduction of reactive oxygen species (ROS) and enhanced mitochondrial efficiency.

Laboratory Protocol & Handling

Storage & Stability
Supplied lyophilised for maximum sequence integrity during logistics.

Dry Storage: -20°C for >12 months; 2-8°C for <6 months.
Liquid Stability: Must be refrigerated (2-8°C) once reconstituted.
Solubility: Water (1mg/ml) or sterile physiological saline.

Reconstitution SOP
Strict adherence to laboratory SOPs is required to maintain the 16-amino acid chain.

Solvent: Sterile Bacteriostatic Water or PBS.
Technique: Slow sidewall induction; do not agitate the puck.
Unit Sizes: 40mg precision research configurations.

Strict Laboratory Compliance Notice

WARNING: This compound is a chemical reagent supplied exclusively for in-vitro and in-vivo laboratory research. It is NOT a drug, medication, or food supplement. Strictly prohibited for human or veterinary administration. Lawful handling is the sole responsibility of the professional user. HRS Distribution assumes no liability for applications outside of laboratory scientific research.